Screening

The references below contain details on screening for effective metal removal procedures and also comprehensive lists of  reagents/scavengers.

OPRD, 2011, 15, 1371–1376 Screening Binary Systems of Chelating Agents Combined with Carbon or Silica Gel Adsorbents: The Development of a Cost-Effective Method to Remove Palladium from Pharmaceutical Intermediates and APIs

Transition Metal-Catalyzed Couplings in Process Chemistry (2013), 313-355 Large-scale applications of transition metal removal techniques in the manufacture of pharmaceuticals

OPRD, 2015, 19, 935 Case Studies in the Development of Drug Substance Control

OPRD, 2005, 9, 198-205 Adsorbent Screening for Metal Impurity Removal in Pharmaceutical Process

OPRD, 2014, 18, 626–635 A Statistical DoE Approach to the Removal of Palladium from Active Pharmaceutical Ingredients (APIs) by Functionalised Silica Adsorbents

Adv. Synth. Catal., 2004, 346, 889 ―900 The Art of Meeting Palladium Specifications in Active Pharmaceutical Ingredients Produced by Pd-Catalyzed Reactions

Comprehensive Chirality, 2012, 9, 209-227 Catalyst recovery and recycle: metal removal techniques

QSAR & Combinatorial Science 2007, 26, 679-685 A high-throughput methodology for screening solution-based chelating agents for efficient palladium removal