Scale-up Issues
The use of solids (carbons or functionalised materials) as metal scavengers has become very commonplace. While it is quite feasible to add these to batch reactors for metal removal, this does give rise to potential issues with reactor cleaning after the clean up operation. This can be avoided by the use of packed columns or beds.
OPRD, 2011, 15, 1396- 1405 Scaling up Metal Scavenging Operations for Pharmaceutical Pilot