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Direct C-H Activation

Mechanism + Description

Mainly via generation of nitrenes and subsequent insertion into A proximal or inter molecular C-H bond

General comments

An emerging area is direct amination of C-H bonds at sp3  centres to create linear amines or heterocycles.  Typically di-rhodium  catalysts are employed. Potentially a very quick and green way to assemble amines, but somewhat hindered in uptake by the catalysts and the generation of the nitrene is often accommodated by poor mass economy chemistry. Amines with electron-withdrawing groups preferred (N-tosyl etc)

Key references

Org. Process Res. Dev., 2011, 15  758–762 Rhodium-Catalyzed C–H amination, an Enabling Method for Chemical Synthesis