Specific Solvent Issues with Fluorination
A key issue is safety. Many F+ reagents can react with common solvents—sometimes explosively. Before any reaction, the compatibility of the fluorinating reagent and solvent should be assessed.
There are very few solvents that can safely be used with F2/N2 mixtures. MeCN, HCO2H, H2SO4 have been reported as compatible with F2/N2 mixtures.
Selectfluor reacts rapidly and exothermically with DMF, pyridine and DMSO.
A number of fluorination reactions have been reported under solvent-free conditions.
The cationic N-F fluorinating agents can be used in water. For a review of fluorination in aqueous media, see: