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Specific Solvent Issues with Borylation Reactions

Many 1st generation borylations via C-H activation and Ir catalysis used n-hexane or benzene as solvents. These should be avoided. n-hexane is neurotoxic and benzene is a carcinogen.

For safety issues, diethyl ether should be avoided/substituted in lithiation reactions. 2-Methyl THF is preferable to THF.

See also specific solvent issues with Suzuki-Miyaura Reactions.

Sherwood, J.; Clark, J. H.; Fairlamb, I. J. S.; Slattery, J. M. Solvent effects in palladium-catalyzed cross-coupling reactions. Green Chem. 2019, 21, 2164-2213.