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Hypervalent Iodine Reagents – General Overview

Organoiodine(V) reagents in organic synthesis

Organohypervalent iodine reagents have attracted significant recent interest as versatile and environmentally benign oxidants with numerous applications in org. synthesis.

This perspective summarizes synthetic applications of hypervalent iodine(V) reagents: 2-iodoxybenzoic acid (IBX), Dess-Martin periodinane (DMP), pseudocyclic iodylarenes, and their recyclable polymer-supported analoges. Recent advances in the development of new catalytic systems based on the generation of hypervalent iodine species in situ are also outlined.

Journal of Organic Chemistry, 2011, 76(5), 1185-1197 – Hypervalent Iodine reagents overview

Hypervalent iodine reagents for the oxidation of alcohols and their application to complex molecule synthesis

A review. Hypervalent iodine (V) derivs. such as 2-iodoxybenzoic acid (IBX) and Dess-Martin periodinane [DMP; 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one] are used widely for the oxidn. of alcs. to aldehydes and ketones during the last decade because of their high chemoselectivity, mild reactivity, and high yielding process. This review focuses on the recent progress in the oxidn. of alcs. to carbonyl compds. using IBX, DMP, and other hypervalent iodine reagents, and their application to total syntheses of a variety of complex natural products.

Advanced Synthesis & Catalysis, 2004, 346(2+3), 111-124. – Complex product oxidation with hypervalent iodine